Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
rAAV1-PG9DP
- Development stage
- Phase 1
- Lead developer
- Children's Hospital of Philadelphia
- Modality
- AAV Vectors → Viral Vectors → Gene Addition/Replacement → Gene Therapies
- Administration
- Intramuscular
01
Overview
rAAV1-PG9DP is a recombinant adeno-associated virus serotype 1 (rAAV1) vector-based gene therapy designed to deliver the gene encoding PG9, a broadly neutralizing human monoclonal IgG1 antibody targeting the V1V2 loop of the HIV-1 envelope gp120 protein. The therapy aims to induce sustained in vivo expression of PG9 antibody following intramuscular injection, providing immunoprophylaxis against HIV infection. Developed as an alternative to traditional vaccination, this approach leverages AAV-mediated delivery for long-term antibody production. The drug was initially developed by The Children's Hospital of Philadelphia and has been evaluated in phase 1 clinical trials for safety, tolerability, and immunogenicity in healthy adult males[2][3][6].
- Other names
- rAAV1-PG9DPrAAV-1-PG9DPrAAV 1-PG9DPAAV1-PG9AAV-1-PG9AAV 1-PG9
02
Targets
V1/V2 glycan (HIV-1 gp120 V1/V2 glycan region)
Beyond the preview
Go deeper on rAAV1-PG9DP.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on rAAV1-PG9DP.