Drug intelligence / Profile preview

rabies vaccine, purified vero cell + equine rabies immunoglobulin

Development stage
Unknown
Lead developer
Sanofi
Modality
Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

This drug is a **combination therapy** used for *rabies post-exposure prophylaxis*. It consists of two components: - **Rabies vaccine, purified vero cell** (PVRV): An inactivated rabies virus vaccine produced using Vero cells, highly purified to minimize impurities and residual host DNA. The vaccine stimulates the immune system to produce neutralizing antibodies against rabies virus, thereby providing active immunization[2][3][4][6][7]. - **Equine rabies immunoglobulin** (ERIG): Purified antibodies from horses immunized with rabies virus, providing immediate passive immunity by neutralizing rabies virus at the site of exposure[5]. ERIG is typically heat-treated to increase purity and safety[5]. The combination is indicated for *post-exposure prophylaxis*—PVRV to induce long-term immunity and ERIG for immediate protection before the vaccine-induced immune response becomes effective[5].

Brand names
Favirab
Other names
PVRV + pERIGPVRVpurified vero cell rabies vaccinepERIGpurified equine rabies immunoglobulin
02

Targets

RABV-G (Rabies virus glycoprotein)

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