Drug intelligence / Profile preview

rabies vaccine (serum-free vero cell) for human use, freeze-dried

Development stage
Phase 3
Lead developer
Ningbo Rong'an Biological Pharmaceutical
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

The freeze-dried human rabies vaccine (serum-free Vero cell) is an inactivated viral vaccine developed by Ningbo Rong'an Biological Pharmaceutical (a subsidiary of AIM Vaccine) for the prevention of rabies. Unlike traditional Vero cell-based rabies vaccines that utilize animal serum (such as newborn calf serum) during the cell culture process, this iterative vaccine is produced using a serum-free Vero cell culture platform. This formulation eliminates animal serum residues, thereby significantly reducing the risk of allergic reactions and other adverse events associated with heterologous proteins. The vaccine has completed Phase III clinical trials in China, demonstrating favorable safety, immunogenicity, and immunological persistence, and its new drug application (NDA) was accepted by the National Medical Products Administration (NMPA) in April 2025.

Other names
freeze-dried human rabies vaccine (serum-free Vero cell)freeze-dried human rabies vaccine (without serum Vero cells)iterative serum-free rabies vaccineserum-free iterative rabies vaccineserum-free Vero cell rabies vaccine
02

Targets

RABV-G (Rabies virus glycoprotein)

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