Drug intelligence / Profile preview

rabies vaccine (Vero cell) (CpG adjuvanted)

Development stage
Preclinical
Lead developer
Zhuoyi Biological
Modality
Prophylactic Vaccines → Vaccines & Immunotherapeutics, Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

Rabies vaccine (Vero cell) (CpG adjuvanted) is a prophylactic vaccine candidate being developed by Zhuoyi Biological for the prevention of rabies. The vaccine is produced using Vero cell culture technology and is formulated with a CpG oligodeoxynucleotide adjuvant. This adjuvant functions as a Toll-like receptor 9 (TLR9) agonist, which stimulates the innate immune system and enhances the production of type I interferons and pro-inflammatory cytokines. The source context also attributes the mechanism to the STING (Stimulator of Interferon Genes) pathway, which plays a crucial role in sensing DNA and mediating immune activation. By combining the rabies antigen with this potent adjuvant, the vaccine aims to provide robust and long-lasting protection against rabies virus infection. It is currently in the IND-enabling or early clinical development stage.

Other names
冻干人用CpG佐剂狂犬病疫苗(Vero细胞)CpG-adjuvanted rabies vaccine (Vero cell)rabies vaccine (Vero cell)-Zhuoyi Biological-STING-prophylactic vaccine-adjuvanted vaccine-Rabies
02

Targets

STING (Stimulator of interferon genes protein)TLR9 (Toll-like receptor 9)

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