RADA16

RADA16 nanopeptide gel, marketed under the brand name PuraStat, is a fully synthetic self-assembling peptide (SAP) hydrogel developed by 3D-Matrix. The active ingredient is a 16-amino acid polypeptide (Ac-RADARADARADARADA-NH2) composed of four naturally occurring amino acids repeated four times. In its acidic formulation, RADA16 exists as a viscous solution; however, upon contact with physiological fluids such as blood (neutral/alkaline pH), the peptides spontaneously self-assemble into beta-sheet nanofibers that rapidly crosslink into a stable, transparent 3D hydrogel matrix. This matrix mimics the native extracellular matrix and acts as a mechanical barrier to provide rapid haemostasis and support mucosal wound healing. It is primarily used as a topical haemostatic agent in various surgical procedures, including endoscopic nasal surgery and gastrointestinal endoscopy, to control bleeding and prevent postoperative complications such as adhesions (synechiae) and crusting.

Brand names

PuraStat

Other names

RADA16 nanopeptide gelRADA-16 nanopeptide gelRADA 16 nanopeptide gelRADA16 haemostatic gelRADA-16 haemostatic gelRADA 16 haemostatic gelRADA16 hydrogelRADA-16 hydrogelRADA 16 hydrogelRADA16 self-assembling peptideRADA-16 self-assembling peptideRADA 16 self-assembling peptide