rADAMTS13 R1206K

**rADAMTS13 R1206K** is a recombinant variant of human ADAMTS13 metalloprotease engineered with a point mutation (arginine to lysine at position 1206) to enhance enzymatic activity. It exhibits significantly increased proteolytic activity compared to wild-type rADAMTS13 in cleaving von Willebrand factor (VWF) multimers and surrogate VWF substrates, potentially improving regulation of VWF-platelet interactions and reducing microthrombi formation in thrombotic thrombocytopenic purpura (TTP). This variant addresses limitations in standard rADAMTS13 (e.g., Adzynma) by offering higher specific activity, with research highlighting its role in arginine methylation regulation at R1206 for secretion and function.[3][5][13]