radioiodine-labeled human serum albumin

Radioiodine-labeled human serum albumin is a **diagnostic radiopharmaceutical** comprised of **human serum albumin** covalently labeled with a radioactive iodine isotope (most commonly iodine-125 or iodine-131)[1][2][6][7]. After intravenous injection, it remains primarily within the vascular compartment, enabling accurate measurement of blood volume, plasma volume, vascular permeability, and assessment of protein-losing gastroenteropathy through quantitative detection of the radiolabel using gamma cameras or other nuclear medicine techniques[1][5][6][7]. The primary mechanism involves tracking the distribution and clearance of albumin in the body using the radioisotope signal. The drug's developer and manufacturer are most notably **GE Healthcare** for Jeanatope (I-125 albumin); other formulations are produced by various diagnostic radiopharmaceutical manufacturers[5]. The drug is not for treatment but serves as a diagnostic agent in nuclear medicine.

Brand names

JeanatopeVolumexMegatope

Other names

iodinated I-125 albuminiodinated I-131 albuminradioiodinated serum albuminradio-iodinated human serum albuminradioiodine-labeled human albumin