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radix astragali
- Development stage
- Phase 3
- Lead developer
- Nanfang Hospital, Southern Medical University
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Radix Astragali, the dried root of *Astragalus membranaceus* or *Astragalus mongholicus*, is a prominent herb in Traditional Chinese Medicine (TCM) known as Huangqi. It contains a variety of bioactive compounds, including astragalosides (saponins), flavonoids, and polysaccharides. In clinical settings, it is being evaluated for its ability to induce fetal hemoglobin (HbF) synthesis in non-transfusion-dependent beta-thalassemia patients, which may help improve anemia. Additionally, it has been studied for its role in modulating P-glycoprotein (P-gp) mediated drug transport and for its hypoglycemic effects in patients with pre-diabetes and type 2 diabetes mellitus. The herb is recognized for its immunomodulatory, antioxidant, and renoprotective properties.
- Other names
- astragalus rootHuangqiAstragalus membranaceus rootAstragalus root extract
02
Targets
HBG2 (Hemoglobin subunit gamma-2)ABCB1 (P-glycoprotein)
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