radix bupleuri aqueous extract

Radix bupleuri aqueous extract is a botanical preparation derived from the dried root of *Bupleurum* species, most commonly *Bupleurum chinense* or related sources used in traditional East Asian medicine. Based on the provided publication, it is being investigated preclinically for schizophrenia, where oral administration in an MK-801 mouse model was reported to reduce schizophrenia-like behaviors, decrease hippocampal inflammatory signaling and microglial activation, normalize dopamine and serotonin abnormalities, increase synaptic markers and brain-derived neurotrophic factor, improve intestinal barrier integrity, and alter gut microbial composition. Its pharmacology appears pleiotropic rather than driven by a single defined molecular target, with activity consistent with a multi-component botanical extract exerting anti-inflammatory, neuroprotective, and microbiome-modulating effects.

Other names

radix bupleuri extractBupleurum chinense aqueous extractbupleuri radix aqueous extractchai hu aqueous extract