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RAG-20

Development stage: Preclinical
Lead developer: Ractigen Therapeutics
Modality: mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intravenous

Overview

RAG-20 is a small activating RNA (saRNA) therapeutic developed by Ractigen Therapeutics for the treatment of coagulation disorders. Utilizing the RNA activation (RNAa) mechanism, RAG-20 is designed to upregulate the endogenous expression of Factor VII (FVII) in the liver. The drug is delivered using Ractigen's proprietary GLORY™ liver-specific delivery technology. It is currently in preclinical development for indications including Factor VII deficiency, hemophilia with inhibitors (including acquired hemophilia), and Glanzmann's thrombasthenia.

Targets

F7 (Coagulation Factor VII)

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