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ragweed-spire
- Development stage
- Phase 2
- Lead developer
- NIOX
- Modality
- Vaccines & Immunotherapeutics, Peptides
- Administration
- Intradermal
01
Overview
Ragweed-SPIRE is an investigational immunotherapy product developed for the treatment of ragweed pollen allergy (seasonal allergic rhinitis). It is based on synthetic peptide immuno-regulatory epitopes (SPIREs) derived from the major allergen in ragweed pollen. The therapy aims to induce immune tolerance by targeting T-cell responses, thereby reducing allergic symptoms upon exposure to ragweed pollen. In clinical studies, Ragweed-SPIRE was administered as a short-course regimen prior to the start of the ragweed season and demonstrated dose-dependent improvements in allergy symptoms compared with placebo. The product was well-tolerated with no significant safety issues reported in trials[5][1].
- Other names
- Ragweed-SPIRE
02
Targets
MHC II (Major histocompatibility complex class II receptor)γδ TCR (T-cell receptor)
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