Drug intelligence / Profile preview

Ramipril + hydrochlorothiazide

Development stage
Unknown
Lead developer
Sanofi
Modality
Small Molecules
Administration
Oral
01

Overview

Ramipril + hydrochlorothiazide is a fixed-dose combination medication used to treat high blood pressure (hypertension). It combines two active ingredients: ramipril, an angiotensin-converting enzyme (ACE) inhibitor, and hydrochlorothiazide, a thiazide diuretic. Ramipril works by blocking the conversion of angiotensin I to angiotensin II, leading to relaxation of blood vessels and reduced blood pressure. Hydrochlorothiazide increases urine output by inhibiting sodium reabsorption in the distal tubules of the kidney, which helps remove excess water and salt from the body. This combination is prescribed when monotherapy with either agent does not adequately control blood pressure[1][3][8].

Brand names
Altace HCTRamipril-HCTZRan-Ramipril HCTZ
Other names
ramipril and hydrochlorothiazideramipril/hydrochlorothiazide
02

Targets

ACE (Angiotensin Converting Enzyme)SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)

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