ramipril + amlodipine + hydrochlorothiazide

Tonotec HCT is a fixed-dose combination antihypertensive medication developed and marketed by Apontis Pharma. It contains three active ingredients: ramipril, amlodipine, and hydrochlorothiazide. Ramipril is an angiotensin-converting enzyme (ACE) inhibitor that prevents the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby reducing peripheral vascular resistance. Amlodipine is a dihydropyridine calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle, resulting in peripheral vasodilation. Hydrochlorothiazide is a thiazide diuretic that acts on the distal convoluted tubule of the kidney to inhibit sodium and chloride reabsorption, leading to increased sodium and water excretion and a reduction in extracellular fluid volume. This triple combination is indicated for the treatment of hypertension in patients whose blood pressure is not sufficiently controlled by dual therapy.

Brand names

Tonotec HCT