ramipril + indapamide

Ramipril + indapamide is a fixed-dose combination pharmaceutical composition used for the treatment of hypertension. It combines two antihypertensive agents with complementary mechanisms of action: ramipril, an angiotensin-converting enzyme (ACE) inhibitor, and indapamide, a thiazide-like diuretic. Ramipril works by inhibiting the conversion of angiotensin I to the potent vasoconstrictor angiotensin II, thereby reducing peripheral vascular resistance and aldosterone secretion. Indapamide acts primarily on the distal convoluted tubules of the kidney to inhibit the sodium-chloride symporter, promoting the excretion of sodium and water and reducing peripheral vascular resistance through a direct vasodilatory effect. This combination is particularly effective for patients whose blood pressure is not adequately controlled by monotherapy, providing synergistic blood pressure reduction and potentially reducing the risk of cardiovascular events such as stroke and myocardial infarction.

Brand names

Pramind

Other names

Ramipril/Indapamide