ramiprilat

Ramiprilat is the active metabolite of ramipril, an angiotensin-converting enzyme (ACE) inhibitor. Ramipril itself is a prodrug that, after oral administration, is hydrolyzed in the liver to form ramiprilat. Ramiprilat exerts its pharmacological effects by inhibiting ACE, thereby blocking the conversion of angiotensin I to angiotensin II—a potent vasoconstrictor—and reducing aldosterone secretion. This leads to vasodilation, decreased blood pressure, and reduced workload on the heart. The primary clinical uses of its parent compound (ramipril) include treatment of hypertension, heart failure (especially post-myocardial infarction), and reduction of cardiovascular risk in high-risk patients[1][3][5][7]. Ramiprilat itself is not typically administered directly as a drug but represents the bioactive form responsible for these therapeutic effects.