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Drug intelligence / Profile preview
ranitidine + domperidone
- Development stage
- Phase 4
- Lead developer
- Thrift Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
RAX-D is an oral fixed-dose combination therapy containing ranitidine hydrochloride and domperidone, developed and marketed by Thrift Pharmaceuticals. Ranitidine is a histamine H2-receptor antagonist that reduces stomach acid production, while domperidone is a peripheral dopamine D2 and D3 receptor antagonist that acts as a prokinetic agent to enhance gastric motility and accelerate stomach emptying. This combination is indicated for the treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, hyperacidity, and associated symptoms such as heartburn, nausea, and vomiting.
- Brand names
- RAX-D
- Other names
- ranitidine HCl + domperidoneranitidine hydrochloride + domperidone
02
Targets
ButyrylcholinesteraseDRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)HRH2 (Histamine H2 Receptor)
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