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RAS Pathway Interceptor
- Development stage
- Preclinical
- Lead developer
- Apertor Pharmaceuticals
- Modality
- Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
01
Overview
Apertor Pharmaceuticals is developing a RAS Pathway Interceptor, a heterobifunctional molecule designed to selectively disrupt protein-protein interactions (PPIs) within the RAS signaling pathway. Unlike traditional small molecule inhibitors that target enzymatic pockets, these "Interceptors" are engineered to block the interfaces where RAS interacts with its effectors or regulators, potentially overcoming resistance mechanisms associated with direct RAS inhibition. The program is currently in the discovery phase and is being evaluated for the treatment of RAS-driven malignancies, including non-small cell lung cancer (NSCLC), pancreatic cancer, and colorectal cancer.
- Other names
- RAS Pathway Interceptor
02
Targets
RAS-effector protein-protein interface
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