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Rasdegafusp alfa

Development stage: Discontinued
Lead developer: Celldex Therapeutics
Modality: Cancer Vaccines → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intracutaneous, Intradermal, Subcutaneous

Overview

Rasdegafusp alfa (CDX-1401) is a DEC-205/NY-ESO-1 fusion protein vaccine. It consists of a monoclonal antibody directed against the dendritic cell receptor DEC-205 linked to the tumor-associated antigen NY-ESO-1. This design aims to deliver NY-ESO-1 to dendritic cells, thereby boosting the immune system to attack cancer cells expressing NY-ESO-1. It was developed by Celldex Therapeutics Inc, National Cancer Institute (USA), Roswell Park Cancer Institute, and Ludwig Institute for Cancer Research for the treatment of solid tumors and various hematological malignancies.

Other names: DEC-205/NY-ESO-1 fusion protein CDX-1401

Targets

LY75 (Dendritic cell receptor DEC–205)NY-ESO-1 (New york esophageal squamous cell carcinoma 1)

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