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Raxibacumab
- Development stage
- Approved
- Lead developer
- GSK
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
Raxibacumab is a fully human IgG1λ monoclonal antibody indicated for the treatment and prophylaxis of inhalational anthrax due to Bacillus anthracis, in combination with appropriate antibacterial drugs. It works by binding to the protective antigen (PA) component of B. anthracis toxin, thereby blocking its interaction with cellular receptors and preventing the entry of lethal factor and edema factor into cells. This neutralizes the pathogenic effects of anthrax toxin but does not have direct antibacterial activity. Raxibacumab was originally developed by Human Genome Sciences (HGS), later acquired by GlaxoSmithKline, and is currently manufactured by Emergent BioSolutions. The drug was approved by the FDA on December 14, 2012.
- Brand names
- Raxibacumab
02
Targets
PA (Influenza polymerase acidic protein)
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