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**RayGel** is an investigational topical gel developed by Integrative Therapies for prevention or reduction of acute radiation dermatitis during external-beam radiotherapy for breast cancer. It contains reduced glutathione and anthocyanin extracts from blue/purple flowering plants. Its proposed activity is local antioxidant and cytoprotective support against radiation-associated oxidative skin injury; no discrete molecular target or validated target-binding mechanism has been established. In a small randomized, blinded study of patients receiving whole-breast irradiation, RayGel was associated with a lower mean skin-reaction score than placebo. ([americanjournalofsurgery.com](https://www.americanjournalofsurgery.com/article/S0002-9610%2805%2900158-3/fulltext))
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