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RBD SARS-CoV-2 HBsAg virus-like particle vaccine
- Development stage
- Unknown
- Lead developer
- Serum Institute of India
- Modality
- Split/Subunit Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Recombinant Protein Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Cancer Vaccines → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
The RBD SARS-CoV-2 HBsAg virus-like particle vaccine (LY01020) is a recombinant protein subunit vaccine candidate developed by Shandong Boan Biotechnology, a subsidiary of Luye Pharma. The vaccine utilizes a virus-like particle (VLP) platform where the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is displayed on the surface of Hepatitis B surface antigen (HBsAg) particles. This multivalent presentation is designed to mimic the structure of a virus and enhance the B-cell response and overall immunogenicity compared to monomeric RBD proteins. The formulation includes two adjuvants: aluminum hydroxide (alum) and CpG 1018, a Toll-like receptor 9 (TLR9) agonist, to further boost the immune response and promote a Th1-biased profile. Clinical development has proceeded through Phase I/II trials in Australia, managed by the CRO Accelagen, evaluating the safety and immunogenicity of the vaccine in healthy adults.
- Other names
- RBD-HBsAg VLP vaccineRBD-based SARS-CoV-2 HBsAg VLP vaccineRBD SARS-CoV-2 HBsAg VLP vaccine
02
Targets
HBsAg (Hepatitis B surface antigen)ACE2 (Angiotensin-converting enzyme 2)Naïve B-cell receptors specific for SARS-CoV-2 receptor-binding domain epitopesRBD (SARS-CoV-2 spike receptor-binding domain)
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