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RBI-2000
- Development stage
- Preclinical
- Lead developer
- Replicate Bioscience
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intratumoral
01
Overview
RBI-2000 is an investigational **lipid nanoparticle-encapsulated self-replicating RNA** therapeutic developed by Replicate Bioscience for solid tumors. The single alphavirus-derived srRNA vector encodes two biotherapeutic proteins: **interleukin-12** to stimulate antitumor immune-cell generation, infiltration, activation, and effector function, and an **interleukin-1 receptor antagonist** to reduce IL-1-driven sterile inflammation, aberrant angiogenesis, and tumor invasiveness. In preclinical murine MC38 tumor models, intratumoral RBI-2000 produced durable protein expression, tumor control, immunologic memory after rechallenge, and enhanced activity when combined with a checkpoint inhibitor.
- Other names
- RBI 2000RBI2000RBI-2000
02
Targets
IL1R1 (Interleukin-1 Receptor Type 1)IL12RB2 (Interleukin-12 receptor subunit beta-2)
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