rcApt

rcApt is a computationally designed single-stranded DNA aptamer engineered to disrupt the protein-protein interaction between RAD51 and BRCA2. By specifically binding to the RAD51 recombinase at the site where it normally interacts with BRCA2, rcApt prevents the formation of the RAD51-BRCA2 complex essential for homologous recombination (HR) DNA repair. This inhibition leads to the impairment of RAD51 nuclear localization and the accumulation of DNA double-strand breaks. rcApt has shown potential in sensitizing cancer cells, particularly pancreatic cancer cells, to PARP inhibitors like olaparib through a synthetic lethality approach. Preclinical studies using 3D spheroid models have demonstrated its efficacy in reducing DNA repair efficiency and promoting cancer cell death.

Other names

RAD51-targeting aptamerRAD-51-targeting aptamerRAD 51-targeting aptamerRAD51-BRCA2 interaction inhibitorRAD-51-BRCA2 interaction inhibitorRAD 51-BRCA2 interaction inhibitor