RCH-2

RCH-2 is a small molecule phytocompound isolated from the creosote bush (*Larrea tridentata*) that functions as a transcriptional inhibitor of the Sp1 transcription factor. Developed by researchers at Academia Sinica, RCH-2 has demonstrated potent anti-tumor activity in preclinical models of glioblastoma. Its mechanism of action involves the suppression of tumor growth through direct Sp1 inhibition and the modulation of the immune system. Specifically, RCH-2 induces Th2 cytokines and promotes the production of anti-tumor antibodies, which facilitate antibody-dependent cell-mediated cytotoxicity (ADCC) and natural killer (NK) cell-mediated lysis of tumor cells. RCH-2 has also shown synergistic effects when combined with various chemotherapeutic agents, suggesting its potential as part of a combination therapy regimen for glioblastoma.

Other names

3-O-methylnordihydroguaiaretic acid3-O-methyl-nordihydroguaiaretic acid