rClone30-IL-12

rClone30-IL-12 is a genetically engineered oncolytic Newcastle disease virus (NDV) based on the Clone 30 strain, designed to express the cytokine interleukin-12 (IL-12). As an oncolytic virus, it selectively infects and lyses tumor cells while simultaneously delivering IL-12 to the tumor microenvironment. IL-12 is a potent immunomodulator that stimulates T-cell and natural killer (NK) cell activity and promotes the secretion of interferon-gamma (IFN-γ), thereby enhancing the host's anti-tumor immune response. Preclinical studies have demonstrated its efficacy in inhibiting tumor growth and improving survival in various cancer models, including hepatoma and glioma.

Other names

recombinant Newcastle disease virus expressing interleukin-12