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rClone30-IL-12
- Development stage
- Preclinical
- Lead developer
- Northeast Agricultural University
- Modality
- Oncolytic Viruses → Oncolytic Therapeutics, Cytokines & Interferons → Recombinant Proteins and Enzymes
- Administration
- Intratumoral
01
Overview
rClone30-IL-12 is a genetically engineered oncolytic Newcastle disease virus (NDV) based on the Clone 30 strain, designed to express the cytokine interleukin-12 (IL-12). As an oncolytic virus, it selectively infects and lyses tumor cells while simultaneously delivering IL-12 to the tumor microenvironment. IL-12 is a potent immunomodulator that stimulates T-cell and natural killer (NK) cell activity and promotes the secretion of interferon-gamma (IFN-γ), thereby enhancing the host's anti-tumor immune response. Preclinical studies have demonstrated its efficacy in inhibiting tumor growth and improving survival in various cancer models, including hepatoma and glioma.
- Other names
- recombinant Newcastle disease virus expressing interleukin-12
02
Targets
IL-12R (Interleukin-12 receptor)
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