rClone30-IL24

rClone30-IL24 is a recombinant Newcastle disease virus (NDV) engineered to express human interleukin-24 (IL-24). NDV is a member of the paramyxovirus family used as an oncolytic virus, naturally selective for tumor cells due to defects in their antiviral responses. By delivering IL-24—a tumor-suppressive cytokine with selective pro-apoptotic effects on cancer cells—directly into tumors, this construct aims to enhance antitumor immune responses and induce cancer cell death through multiple mechanisms, including activation of the JAK-STAT signaling pathway, increased reactive oxygen species (ROS) production, and upregulation of tumor suppressor proteins such as p53 and p21. This platform is under preclinical or early clinical investigation for solid tumors, with initial studies focusing on hepatocellular carcinoma and other malignancies.