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RdCVFL
- Development stage
- Unknown
- Lead developer
- SparingVision
- Modality
- Gene Therapies, Recombinant Proteins and Enzymes
- Administration
- Intravitreal, Ophthalmic
01
Overview
RdCVFL (rod-derived cone viability factor long form) is an investigational research protein and the long isoform encoded by the nucleoredoxin-like 1 (NXNL1) gene. Unlike the short isoform RdCVF, which acts as a secreted trophic factor promoting glucose uptake, RdCVFL is a thioredoxin-like, redox-active enzyme that protects photoreceptors from oxidative stress and exhibits chaperone and S-denitrosylase activity. It is not developed as a standalone commercial product but is a key component of SPVN06, an AAV-based, mutation-agnostic gene therapy developed by SparingVision. SPVN06 expresses both RdCVF and RdCVFL and is in Phase I/II clinical development for the treatment of retinitis pigmentosa and other rod-cone dystrophies.
- Other names
- RdCVF-Lrod-derived cone viability factor long formrod-derived cone viability factor long isoformthioredoxin-like protein rod-derived cone viability factor
02
Targets
MAPT (Microtubule-associated protein tau)
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