Drug intelligence / Profile preview

Reactive Skin Decontamination Lotion

Development stage
Unknown
Lead developer
SERB Pharmaceuticals
Modality
Small Molecules, Hydrogel Systems → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems
Administration
Topical
01

Overview

Reactive Skin Decontamination Lotion (RSDL) is a topical decontaminant specifically formulated to neutralize and remove chemical warfare agents (CWAs) such as nerve agents (e.g., VX, Sarin/GB, Soman/GD), blister agents (e.g., sulfur mustard/HD, Lewisite), T-2 mycotoxin, and certain toxic industrial chemicals from the skin. The active ingredients are Dekon 139 (potassium 2,3-butanedione monoximate/KBDO) and 2,3-butanedione monoxime (DAM), dissolved in a glycol-based solvent system. The mechanism of action involves rapid nucleophilic substitution reactions that neutralize organophosphorus compounds and other toxins by breaking their chemical bonds or denaturing them. RSDL is applied topically using a foam applicator; it acts within minutes to detoxify contaminants on the skin surface. It is FDA-cleared as a medical device for emergency use in chemical exposures[2][3][5][6][10].

Brand names
RSDL
Other names
Reactive Skin Decontamination LotionRSDL Kit
02

Targets

Shiga toxin

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