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Rebeccamycin
- Development stage
- Preclinical
- Lead developer
- Bristol Myers Squibb
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
Rebeccamycin is an indolocarbazole alkaloid and a natural product with antibiotic and antitumoral properties. It functions as a potent inhibitor of kinases and DNA topoisomerase I. It has been investigated in various clinical trials for its effectiveness against a range of solid tumors and hematologic malignancies, and preclinical studies suggest its ability to inhibit cell proliferation and induce apoptosis by downregulating the PI3K/AKT signaling pathway. It also acts as an inhibitor of the fsr quorum sensing system in *Enterococcus faecalis*.
- Other names
- rebeccamycin analoguerebeccamycin analog
02
Targets
DNATOP1 (DNA Topoisomerase I)
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