recombinant aminopeptidase A

Recombinant aminopeptidase A (rAPA) is a recombinant form of the enzyme aminopeptidase A (APA, also known as glutamyl aminopeptidase or ENPEP). APA is a membrane-bound zinc metallopeptidase that plays a key role in the renin-angiotensin system (RAS) by cleaving the N-terminal aspartate residue from various angiotensin peptides, including angiotensin II (Ang II), angiotensin I (Ang I), and angiotensin-(1-12). By degrading these pro-hypertensive peptides, rAPA reduces their pressor effects and mitigates acute systolic blood pressure elevation. It is being investigated as a potential therapeutic approach for the treatment of hypertension resulting from RAS overactivity.

Other names

rAPArecombinant APArecombinant ENPEPrecombinant glutamyl aminopeptidase