recombinant anti-thymocyte globulin

**Recombinant anti-thymocyte globulin** is an investigational fully human recombinant polyclonal antibody preparation developed to reproduce the broad lymphocyte-depleting activity of conventional animal-derived anti-thymocyte globulin while enabling more consistent manufacturing and avoiding anti-animal antibody responses. In reported preclinical work, the product contained diverse human IgG1 antibodies generated from immunized humanized mice and produced in Chinese hamster ovary cells; it bound immune-cell proteins including CD3, CD4, CD5, and CD45, mediated antibody-dependent cellular cytotoxicity, depleted human peripheral blood mononuclear cells, and delayed graft-versus-host disease in a humanized mouse model. ([atcmeetingabstracts.com](https://atcmeetingabstracts.com/abstract/a-recombinant-fully-human-atg-polyclonal-antibody-drug-drives-immune-cell-depletion-in-a-model-of-graft-versus-host-disease/))

Other names

fully human recombinant anti-thymocyte globulinrecombinant human anti-thymocyte globulinrhATG