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recombinant C1 esterase inhibitor
- Development stage
- Preclinical
- Lead developer
- CSL
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
The recombinant C1 esterase inhibitor is a glyco-optimized protein developed by CSL Limited and CEVEC using CEVEC's proprietary CAP(R)Go technology platform. This drug is designed to improve the half-life and provide a more convenient application for patients. Its primary mechanism involves replacing or supplementing the activity of endogenous C1 esterase inhibitor, thereby regulating the complement and contact systems. It is being developed for the treatment of Hereditary Angioedema (HAE) and other potential indications.
- Other names
- C1-INHC-1-INHC 1-INH
02
Targets
MASP2 (Mannan-binding lectin-associated serine protease 2)FXIIa (Coagulation Factor XIIa)MASP1 (MASP-1)C1S (Complement component 1s subcomponent serine protease)Factor XIaC1R (Complement component 1r subcomponent)KLKB1 (Plasma kallikrein)
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