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Drug intelligence / Profile preview
recombinant fowlpox-GM-CSF
- Development stage
- Phase 1
- Lead developer
- National Cancer Institute
- Modality
- Prophylactic Vaccines → Vaccines & Immunotherapeutics, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Recombinant Proteins and Enzymes
- Administration
- Subcutaneous, Intravesical, Intratumoral
01
Overview
A cancer immunotherapy agent consisting of a recombinant fowlpox virus engineered to express human granulocyte-macrophage colony-stimulating factor (GM-CSF). The drug is designed as a vaccine adjuvant to enhance anti-tumor immune responses by recruiting and activating antigen-presenting dendritic cells in the tumor microenvironment, thereby promoting stronger antigen presentation and T-cell mediated immunity. It was primarily developed for use in various cancers, including bladder cancer, breast cancer, hepatocellular carcinoma, rectal adenocarcinoma, recurrent gastric cancer, salivary gland cancers, stage III colon cancer, medullary thyroid cancer, metastatic neoplasms and mammary Paget's disease. The developer is the National Cancer Institute. Clinical development reached Phase 1 but has since been discontinued[1][2][3][6].
- Other names
- recombinant fowlpox gm-csf vaccine adjuvantrFGM-CSF
02
Targets
CSF2R (Granulocyte-macrophage colony-stimulating factor receptor)
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