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Drug intelligence / Profile preview
recombinant hexavalent norovirus vaccine
- Development stage
- Phase 1
- Lead developer
- Chengdu Kanghua Biological Products
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Parenteral
01
Overview
**Recombinant hexavalent norovirus vaccine** is an investigational, Pichia pastoris-expressed virus-like particle vaccine developed by Chengdu Kanghua Biological Products for prevention of norovirus infection and norovirus-associated acute gastroenteritis. The product contains virus-like-particle antigens representing norovirus genotypes GI.1, GII.2, GII.3, GII.4, GII.6, and GII.17. It is administered as an injection and is in randomized, double-blind, placebo-controlled Phase 1 evaluation in healthy participants aged 6 weeks and older in China. ([static.cninfo.com.cn](https://static.cninfo.com.cn/finalpage/2026-01-26/1224950746.PDF))
- Other names
- recombinant hexavalent norovirus vaccine Pichia pastoris重组六价诺如病毒疫苗重组六价诺如病毒疫苗毕赤酵母
02
Targets
BCR-NV-VP1 (B-cell receptor (BCR) specific for norovirus VP1 conformational epitopes)Norovirus VP1TCR-VP1-MHCII (T-cell receptor recognizing VP1-derived peptides presented on MHC class II)GI.1 (Norovirus genotype GI.1)GII.17 (Norovirus genotype GII.17)GII.2 (Norovirus genotype GII.2)Norovirus genotype GII.6
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