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Drug intelligence / Profile preview
recombinant human bone morphogenetic protein 6
- Development stage
- Unknown
- Lead developer
- Genera Research
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Implant, Topical
01
Overview
Recombinant human Bone Morphogenetic Protein 6 (rhBMP6) is a biologic therapeutic belonging to the TGF-β superfamily. It is primarily developed for its potent osteoinductive properties, stimulating the differentiation of mesenchymal stem cells into osteoblasts and chondrocytes to promote bone and cartilage repair. A notable formulation, rhBMP6/ABC (Autologous Blood Graft Substitute), utilizes an autologous blood coagulum as a carrier to avoid the complications associated with bovine collagen scaffolds used in earlier BMP products. It has been investigated in clinical trials for bone healing in high tibial osteotomy and is also being researched for its potential to restore epidermal barrier function in atopic eczema by increasing filaggrin expression.
- Other names
- BMP6BMP-6BMP 6Bone Morphogenetic Protein 6ABGSAutologous Blood Graft SubstituterhBMP6/ABC
02
Targets
ACVR1 (Activin receptor type I)ACVR2A (Activin receptor type 2A)ACVR2B (Activin receptor type IIB)BMPR1ABMPR1BHJV (Hemojuvelin)A2M (Alpha-2-macroglobulin)F2 (Thrombin)BMPR2 (Bone morphogenetic protein receptor type II)
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