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recombinant human endostatin + gemcitabine + cisplatin
- Development stage
- Unknown
- Lead developer
- Simcere Pharmaceutical Group
- Modality
- Small Molecules, Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
A combination therapy consisting of recombinant human endostatin (Endostar), gemcitabine, and cisplatin. This regimen combines an anti-angiogenic agent with traditional chemotherapy drugs. Recombinant human endostatin is a 20 kDa protein derived from type XVIII collagen that inhibits angiogenesis by targeting endothelial cells, while gemcitabine and cisplatin are cytotoxic agents that directly target cancer cells. The combination leverages the ability of endostatin to normalize tumor vasculature, potentially enhancing the delivery and efficacy of the chemotherapy drugs.
- Other names
- Endostar + GPEndostar plus GPrecombinant human endostatin + gemcitabine + cisplatin
02
Targets
DNADNA polymerase familyMMP13 (Matrix metalloproteinase-13)MMP2 (Matrix metalloproteinase-2)MMP9 (Matrix metalloproteinase-9)VEGFR2 (Vascular endothelial growth factor receptor 2)
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