recombinant human hyaluronidase + isotonic hydration fluid

This combination therapy consists of **recombinant human hyaluronidase (rHuPH20)** administered subcutaneously followed by infusion of an **isotonic hydration fluid** (such as normal saline or lactated Ringer’s solution). Recombinant human hyaluronidase temporarily depolymerizes hyaluronan in the subcutaneous extracellular matrix, increasing tissue permeability and facilitating rapid absorption and dispersion of the infused fluids. This enables efficient subcutaneous rehydration, particularly useful in pediatric patients, elderly patients, or others with difficult intravenous access. The approach is approved for mild to moderate dehydration, and clinical studies have found it to be safe and effective, with high success rates for achieving hydration in children with minimal systemic adverse events[1][3][5][7].

Brand names

Hylenex

Other names

rHuPH20-facilitated subcutaneous hydrationrHuPH-20-facilitated subcutaneous hydrationrHuPH 20-facilitated subcutaneous hydrationrHuPH20-enabled hydration therapyrHuPH-20-enabled hydration therapyrHuPH 20-enabled hydration therapy