Drug intelligence / Profile preview

recombinant human interferon alpha-1b + interleukin-2 + thalidomide + venetoclax + azacitidine

Development stage
Unknown
Lead developer
Changchun Institute of Biological Products
Modality
Cytokines & Interferons → Recombinant Proteins and Enzymes, Small Molecules
Administration
Subcutaneous, Intravenous, Oral, Intramuscular
01

Overview

This is a combination therapy consisting of five different agents: 1. Recombinant human interferon alpha-1b: A type I interferon with potent antiviral, antiproliferative, and immunomodulatory properties. It has demonstrated significant anti-SARS-CoV-2 effects in vitro and has potential applications in cancer treatment due to its anti-tumor effects through regulation of cell growth and proliferation. 2. Interleukin-2: An immunomodulatory cytokine that stimulates the growth, proliferation, and differentiation of T cells. 3. Thalidomide: An immunomodulatory drug with anti-angiogenic and anti-inflammatory properties. 4. Venetoclax: A selective BCL-2 inhibitor used in the treatment of certain hematological malignancies. 5. Azacitidine: A hypomethylating agent used in the treatment of myelodysplastic syndromes and acute myeloid leukemia. This combination may be investigated for potential synergistic effects in treating hematological malignancies or other conditions.

02

Targets

BCL-2 (BCL-2 family)DNMT (DNA methyltransferase)IFNAR (Immune system modulation via type I interferon receptor)CRBN (Cereblon)IL-2R (Interleukin-2/interleukin-15 receptor complex)

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