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Drug intelligence / Profile preview
recombinant human mutant tissue-type plasminogen activator
- Development stage
- Unknown
- Lead developer
- Beijing World Trade Dongrui Pharmaceutical Technology
- Modality
- Therapeutic Enzymes → Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
Recombinant human mutant tissue-type plasminogen activator (rhM-tPA) is an investigational thrombolytic biologic developed by Beijing World Trade Dongrui Pharmaceutical Technology. It is a genetically modified version of the endogenous human tissue-type plasminogen activator (tPA), a serine protease responsible for converting plasminogen into plasmin to dissolve fibrin-based blood clots. rhM-tPA is engineered to allow for administration as a single intravenous bolus, which may provide a clinical advantage over the standard-of-care alteplase (rt-PA) that typically requires an initial bolus followed by a continuous infusion. The drug is primarily being developed for the treatment of acute ST-segment elevation myocardial infarction (STEMI) and has been evaluated in Phase II clinical trials to compare its efficacy and safety against alteplase.
- Other names
- rhM-tPArecombinant human mutant tissue-type plasminogen activator
02
Targets
Fibrin (Factor Ia)PLG (Plasminogen)PAI-1 (Plasminogen activator inhibitor type 1)
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