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Drug intelligence / Profile preview
recombinant human phospholipase C-zeta
- Development stage
- Preclinical
- Lead developer
- Weill Cornell Medicine
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Parenteral
01
Overview
Recombinant human phospholipase C-zeta (rhPLCζ) is a recombinant form of the sperm-specific protein phospholipase C-zeta (PLCζ or PLCZ1). It is being developed as a physiological agent for assisted oocyte activation (AOA) in patients undergoing intracytoplasmic sperm injection (ICSI) who have a history of fertilization failure due to sperm activating factor deficiency (PLCζ deficiency). Unlike conventional chemical oocyte activators like ionomycin, rhPLCζ mimics the natural physiological trigger of fertilization by inducing intracellular calcium ([Ca2+]i) oscillations in the ooplasm, which releases the oocyte from meiotic arrest and initiates embryo development.
- Other names
- recombinant human PLC-zetarecombinant human PLCζrecombinant human phospholipase C zeta 1recombinant human phospholipase C-zeta 1rhPLCZrhPLCZ1rhPLCZ-1rhPLCZ 1rhPLCζ
02
Targets
PLCZ1 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta 1)PIP2 (Phosphatidylinositol 4,5-bisphosphate)
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