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recombinant interleukin-12
- Development stage
- Phase 2
- Modality
- Cytokines & Interferons → Recombinant Proteins and Enzymes
- Administration
- Intradermal, Subcutaneous, Intravenous, Intraperitoneal, Intratumoral
01
Overview
Recombinant interleukin-12 (rIL-12) is a cytokine that functions as an immunomodulator, primarily by promoting T-helper 1 (Th1) immune responses. It stimulates the proliferation and activity of cytotoxic T lymphocytes (CD8+ T cells) and natural killer (NK) cells, and induces the production of interferon-gamma (IFN-γ). These actions contribute to its anti-tumor effects, which include direct killing of tumor cells, inhibition of tumor angiogenesis by blocking blood flow, and enhancing vaccine-induced immune responses. Recombinant IL-12 has been investigated for its potential in various cancers and as an adjuvant in vaccines, as well as for its role in hematopoietic recovery and wound healing.
- Other names
- rIL-12rIL12rIL 12hrIL-12hrIL12hrIL 12rhIL-12rhIL12rhIL 12IL-12IL12IL 12edodekin alfaSON-1010SON1010SON 1010
02
Targets
IL12RB2 (Interleukin-12 receptor subunit beta-2)
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