Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
recombinant methioninase
- Development stage
- Unknown
- Lead developer
- AntiCancer
- Modality
- Replacement Enzymes → Therapeutic Enzymes → Recombinant Proteins and Enzymes
- Administration
- Intravenous, Oral
01
Overview
Recombinant methioninase is a recombinant enzyme that depletes methionine, an amino acid essential for the survival and proliferation of many cancer cells. The drug targets "methionine addiction," a metabolic hallmark of cancer known as the Hoffman effect, where cancer cells require exogenous methionine due to increased transmethylation reactions. By degrading circulating methionine, recombinant methioninase selectively arrests cancer cell growth and enhances sensitivity to chemotherapy agents. It has demonstrated efficacy in vitro and in vivo against various cancers including lung, colon, kidney, melanoma (both BRAF-V600E-positive and negative), brain, prostate, ovarian, pancreatic cancers, and triple-negative breast cancer. Recombinant forms have been administered both intravenously and orally in preclinical models and early clinical studies[1][2][3][4][5][8]. Developer: AntiCancer
- Other names
- o-rMETase
Beyond the preview
Go deeper on recombinant methioninase.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on recombinant methioninase.