Drug intelligence / Profile preview

Recombinant Mouse FGL2

Development stage
Unknown
Modality
Recombinant Proteins and Enzymes
01

Overview

Recombinant Mouse FGL2, also known as Fibroleukin, is a 64-70 kDa secreted glycoprotein of the Fibrinogen-like superfamily. It has prothrombinase activity, which requires calcium and acidic phospholipids, and promotes T regulatory (Treg) activity by suppressing DC, T, and B cell immune reactivity. FGL2 is involved in various biological processes, including coagulation, immune regulation, and may play roles in conditions like autoimmune glomerulonephritis and tumor progression.

Other names
Fibroleukin
02

Targets

F2 (Thrombin)FCGR2B (Fc gamma receptor IIB)

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