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recombinant mouse interleukin-11

Development stage: Preclinical
Lead developer: R&D Systems
Modality: Cytokines & Interferons → Recombinant Proteins and Enzymes
Administration: Injection

Overview

Recombinant mouse interleukin-11 (rmIL-11) is a cytokine used primarily as a research tool to investigate the biological effects of IL-11 signaling in murine models. IL-11 is a member of the IL-6 family of cytokines and signals through a heterodimeric receptor complex consisting of the IL-11 receptor alpha (IL-11RA) and the glycoprotein 130 (gp130) subunit. In cardiovascular research, rmIL-11 has been shown to induce cardiomyocyte dysfunction, impair contractility by reducing calcium uptake, and promote profibrotic gene expression in fibroblasts. These effects contribute to heart failure pathologies, particularly Heart Failure with Preserved Ejection Fraction (HFpEF).

Other names: recombinant mouse IL-11mouse interleukin-11

Targets

IL11RA (Interleukin-11 receptor subunit alpha)IL6ST (Interleukin-6 receptor subunit beta)

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