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recombinant murine interferon gamma
- Development stage
- Unknown
- Lead developer
- Bio-Rad Laboratories
- Modality
- Cytokines & Interferons → Recombinant Proteins and Enzymes
- Administration
- In Vitro/in Vivo Experimental, Intraperitoneal (mouse Studies), Subcutaneous (mouse Studies)
01
Overview
Recombinant murine interferon gamma is an E. coli-expressed, full-length, mature form of the mouse interferon gamma cytokine. It is a type II interferon produced by activated T-lymphocytes and natural killer cells, functioning as a key regulator of immune responses. The recombinant protein acts as a potent activator of macrophages, enhances antigen presentation, upregulates MHC class I and II molecules, and acts through the interferon gamma receptor (IFNGR1, IFNGR2), which initiates JAK-STAT signaling cascades. Biological activities include antiviral, antimicrobial, antitumor (anti-proliferative), and immunomodulatory effects. It is used primarily for research applications in studying immune regulation, infection control, and cancer biology in mouse models[1][3][5][7].
- Other names
- recombinant mouse interferon gammaIFN-gammaIfngmurine interferon gamma
02
Targets
IFNGR2 (Interferon gamma receptor 2)IFNGR1 (Interferon gamma receptor 1)
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