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Drug intelligence / Profile preview
recombinant mycobacterium tuberculosis allergen ESAT6-CFP10 + tuberculin purified protein derivative
- Development stage
- Unknown
- Lead developer
- Anhui Zhifei Longcom Biopharmaceutical
- Modality
- Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intradermal
01
Overview
ESAT6-CFP10 + TB-PPD refers to a diagnostic combination used in clinical trials to compare the performance of a novel recombinant tuberculosis skin test against the standard tuberculin purified protein derivative (PPD). ESAT6-CFP10, also known as C-TST or the EC skin test, is a recombinant fusion protein comprising two Mycobacterium tuberculosis-specific antigens: Early Secretory Antigenic Target 6 (ESAT-6) and Culture Filtrate Protein 10 (CFP-10). These antigens are absent in the BCG vaccine and most non-tuberculous mycobacteria, allowing the test to differentiate between TB infection and prior BCG vaccination. Developed by Anhui Zhifei Longcom Biologic Pharmacy, the combination is administered via intradermal injection to evaluate sensitivity and specificity in diagnosing latent and active tuberculosis. The diagnostic readout is based on the diameter of induration at the injection site, reflecting a delayed-type hypersensitivity (DTH) response.
- Brand names
- C-TST
- Other names
- ESAT6-CFP10ESAT-6-CFP10ESAT 6-CFP10TB-PPDrecombinant ESAT-6-CFP-10recombinant Mycobacterium tuberculosis allergen ESAT6-CFP10tuberculin purified protein derivative
02
Targets
MHC I (MHC class I})MHC II (Major histocompatibility complex class II receptor)T-cell receptor specific for ESAT-6/CFP-10 peptide–MHC class I complexesT-cell receptor specific for ESAT-6/CFP-10 peptide–MHC class II complexesT-cell receptor specific for Purified Protein Derivative-derived peptide–Major Histocompatibility Complex class II complexCFP-10 (Culture filtrate protein 10)ESAT-6 (Early secretory antigenic target 6)
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