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recombinant Mycobacterium tuberculosis ESAT6 protein
- Development stage
- Discontinued
- Lead developer
- Abcam
- Modality
- Recombinant Proteins and Enzymes
- Administration
- None (used In Vitro/in Vivo Research Settings; Not Administered Clinically)[1]
01
Overview
Recombinant Mycobacterium tuberculosis ESAT6 protein is a full-length recombinant form of the early secreted antigenic target 6 (ESAT-6) from M. tuberculosis (strain CDC1551), with a predicted molecular weight of approximately 11 kDa[1][2]. It is a secreted protein and acts as a strong T-cell antigen. ESAT-6 plays multiple roles in modulating the host immune response to infection and is responsible for bacterial escape into the host cytoplasm[1]. It belongs to the WXG100 family (ESAT-6 subfamily). Recombinant forms are typically used as research reagents or diagnostic controls; they are not approved for therapeutic or diagnostic use in humans[1]. The main application is as an immunological tool for studying TB pathogenesis and immune responses.
- Other names
- recombinant Mycobacterium tuberculosis 11 kDa proteinESAT-6ESAT6ESAT 6Early Secreted Antigenic Target 6 kDa protein
02
Targets
TCR (T cell antigen receptor complex)
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