recombinant nematode anticoagulant protein c2

Recombinant nematode anticoagulant protein c2 (rNAPc2) is a small, 85-amino acid recombinant protein originally derived from the hookworm *Ancylostoma caninum*. It is a potent and highly specific inhibitor of the Tissue Factor (TF)/Factor VIIa complex, which serves as the primary initiator of the extrinsic coagulation pathway. rNAPc2 possesses a unique, scaffold-dependent mechanism of action: it first binds to a non-catalytic exosite on Factor X (FX) or Factor Xa (FXa), and this binary complex then binds to and inhibits the TF/FVIIa complex. By targeting the initiation phase of coagulation rather than just the propagation phase (like heparin or direct thrombin inhibitors), rNAPc2 effectively prevents thrombin generation. It has been investigated in clinical trials for the prevention of venous thromboembolism in orthopedic surgery, the treatment of acute coronary syndromes, and as a potential therapeutic for the coagulopathy and inflammatory response associated with severe COVID-19 and Ebola virus disease.

Brand names

Anpocogin

Other names

nematode anticoagulant protein c2