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recombinant neutrophil inhibitory factor and hirulog hybrid
- Development stage
- Phase 1
- Lead developer
- Shandong New Time Pharmaceutical
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
Recombinant neutrophil inhibitory factor and hirulog hybrid, also called **TNHH**, is an investigational recombinant hybrid glycoprotein developed for acute ischemic stroke. It combines a neutrophil inhibitory factor-derived component that binds the neutrophil integrin CD11b/CD18 with a hirulog-derived direct thrombin-inhibitory component, aiming to simultaneously limit neutrophil adhesion and migration and reduce thrombin-mediated coagulation at ischemic thrombi. A first-in-human randomized, placebo-controlled, single-ascending-dose study in healthy volunteers evaluated intravenous TNHH at 0.05-1.8 mg/kg; it showed high CD11b/CD18 occupancy at doses above 0.2 mg/kg and dose-related prolongation of thrombin time. The program has been associated with West China Hospital, Chongqing Fagen Biomedical, and Shandong New Time Pharmaceutical.
- Other names
- TNHHtargeted neutrophil inhibitory-hirulog hybridhuman recombinant neutrophil inhibitory factor and hirulog hybrid
02
Targets
αMβ2 (Integrin αMβ2)F2 (Thrombin)
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