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Recombinant novel coronavirus XBB.1.5 variant vaccine is a viral vector vaccine designed to protect against COVID-19 caused by the SARS-CoV-2 XBB.1.5 variant. The specific version described in clinical trials (such as ChiCTR2300075626) utilizes a replication-defective adenovirus type 5 (Ad5) vector to deliver the genetic sequence of the XBB.1.5 spike protein. Developed by CanSino Biologics in collaboration with the Seventh Medical Center of PLA General Hospital, this vaccine is formulated for administration via inhalation. This route is intended to elicit mucosal immunity in the respiratory tract—the primary site of viral entry—in addition to systemic humoral and cellular immune responses. It is primarily positioned as a booster dose for adults who have previously completed a primary vaccination series.
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